Endocrine Abstracts

In contrast to the conventional view of haemochromatosis as a monogenic disease with autosomal recessive inheritance, more recent evidence form genetic, epidemiological, cell biological and clinical studies, challenges this view. The concept that haemochromatosis is an endocrine disorder of mixed etiology embraces the poylgenic nature of the disease, the low penetrance and the similarities in phenotype of genetic and acquired forms of iron overload. Key to understanding haemoc...

Introduction: Hyperprolactinemia is a frequent endocrine disorder with well known harmful effects on the reproductive system and bone metabolism. Besides prolactinomas several drugs and disorders such as renal failure and hypothyroidism have been shown to cause hyperprolactinemia. Based on former studies liver cirrhosis has also been suggested to cause hyperprolactinemia while mechanisms have not been identified yet. In this study we set out to investigate the prevalence and p...